- A study has linked semaglutide, the active component of Ozempic, to A disease that can result in permanent blindness.
- Even though The study has not been documented in a journal, experts have cautioned that it suggests an elevated likelihood of The disease.
- Despite the low cost, the risk is not expected to discourage significant customers from using weight loss products, according to experts.
A recent investigation has revealed that semaglutide, the active ingredient in the popular weight loss medication Ozempic and Wegovy, may be linked to A form of sudden-onset vision deprivation known as NAION. 1.
Another paper has been put forward that suggests semaglutide may be connected to The condition, which is caused by a small boat’s “stroke” of The optic nerve in humans, and can lead to permanent blindness. 2.
Experts caution that the recent findings may not always discourage individuals from attempting semaglutide and other similar drugs. GLP-1, a muscarinic peptide that functions as glucagon. Zepbound and Mounjaro are among the medicines that also include mellitus and weight loss drugs.
It is premature to conclude that the association between semaglutide and NAION is causal, despite the presence of intriguing studies on the topic. Health. ..
Encouragement For the Study.
The authors of The study aimed to investigate The connection between semaglutide and NAION after The previous paper’s correlation was highlighted. Alexander Potteg, MSc, PhD, DMSc is a doctoral candidate. According to the writer of the new study, who is a scientist from Odense University Hospital. Health. The [earliest study] from the United States7abb8 was used as a starting point for this, according to Potteg rd. .
The July study was based on data provided by 710 individuals. Type 2 diabetes. , 979 whom the were. Called fat. Or. Overweight. ..
The study’s authors divided participants into two subtopics, where many had earned a semaglutide prescription and others didn’ t, and found that participants in both types of diabetes and obese/overweight organizations had higher rates of NAION. 3.
According to Potteg, the study appears to be well-coordinated, but it is based on an unusual dataset, which includes data from patients who had contact with a specialist eye doctor.
One of the limitations of this study was that the authors did not know whether all participants who received a prescription for semaglutide took the drugs as directed.
Understanding the Interaction Between Semaglutide and NAION.
Potteg rd and his team examined data from 44,517 individuals in Denmark and 16,860 individuals across Norway, who were all qualified For semaglutide to manage type 2 diabetes.NAION was developed in 24 cases Among the semaglutide consumers in Denmark and eight cases in Norway. .
According to the Authors of the study, NAION may be produced by an additional individual among a group of 10,000 semaglutide consumers in the last year.The researchers determined that NAION is more likely to occur in participants who take semaglutide, but the absolute risk is low. 1.
When it is peer-reviewed and published, I believe this is a study to pay attention to. Alice Tchang, MD. The endo, assistant of clinical Medicine at Weill Cornell Medicine, and overweight Medicine counselor at Ro made the statement. Health. “The investigators conducted multiple analyses to address potential confounders and selection bias, resulting in a similar conclusion as the previous study that NAION may be associated with semaglutide or GLP-1s.”. ” .
Tchang acknowledged That the overall risk of NAION, regardless of GLP-1 usage, is very low. ” .
The probability of a person being one in 10,000 is extremely low, as stated by her.
Experts emphasized that we need not assume NAION is due to semaglutide.Lee suggests that GLP-1 may have a biologically plausible role in the escalation of diabetic eye problems by tightening blood sugar control, which is comparable to the worsening of diabetes retinopathy in similar patients.”The difficulty is that causation is not the same as association.”. Diabetes mellitus. Is NAION a known danger?.
According to Potteg, NAION is not a known side effect of semaglutide.The phenomenon has been investigated in the early stages, and regulators will now assess whether it should be listed.
Although the study is in its early stages, it remains unclear whether semaglutide, a drug that contains mixed ingredients to address individuals with special needs, may have an impact on NAION.
The implications of This apply to individuals who are Considering Ozempic or Wegovy.
The study’s findings that link NAION to semaglutide use should not discourage people from taking the medication unless their doctor instructs them, as per specialists. .
Individuals with NAION may wish to discuss the potential hazards of semaglutide with their medical practitioners.
According to Potteg, this is a rare side effect that most users have no reason to worry about.”In the event that NAION has occurred before or during treatment, patients should be aware that this is likely linked to their use of semaglutide and discontinue using the drug.
The study of NAION and semaglutide usage could lead to a better understanding of individuals at high risk levels, according to experts.”Hopefully, in the future we will be able to better understand this and identify patient subsets that are at risk” Potteg stated.
People who are eligible for semaglutide should be informed about the advantages and disadvantages of taking medication Until that point.
Lee states that additional research is necessary to test the hypothesis.Patients must be informed of their risk profile and make a careful decision in consultation with their care team Until they have that information.
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Simonsen E, Lund LC, Ernst MT, and so forth. . The correlation between the use of Semaglutide and Non-Arteritic Anterior Ischemic Optic Optics Neuropathy was investigated in A Danish-Norwegian Cohort Study. Optometry; 2024. Journal: 10.1101 /2024.12.09.24318574.
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Warren NR and Arnold AC are the authors in question. The latest theories on the diagnosis, comorbidity, and leadership of nonarteritic anterior ischaemic optic neuropathy are available. . Ocular (Lond). 2015; 29 (1): 65-79. Journal: 10.1038 /ocular. 2014.144.
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Among others, Hathaway JT, Shah MP, and Hahaway DB are also involved in the business world. Nonarteritic frontal myocardial eyepiece neuropathy is a potential risk for clients who have been advised to use semaglutide. . JAMA Ophthalmol. 2024; 142 (8): 732. Journal: 10.Ophthalmology (page count: 1001 /jama 2024). 2296.